Endogenous Interleukin-12 Is Not Required for Resolution of Chlamydophila abortus ( Chlamydia psittaci Serotype 1) Infection in Mice
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چکیده
منابع مشابه
Endogenous interleukin-12 is not required for resolution of Chlamydophila abortus (Chlamydia psittaci serotype 1) infection in mice.
A Th1 immune response involving gamma interferon (IFN-gamma) production is required to eliminate Chlamydophila abortus infections. In this study, the role of interleukin-12 (IL-12) in protecting against C. abortus infection was investigated using IL-12(-/-) and wild-type (WT) C57BL/6 mice to determine the role of this Th1-promoting cytokine. IL-12(-/-) mice were able to eliminate the C. abortus...
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Protective monoclonal antibodies (MAbs) to the major outer membrane protein (MOMP) of species of the family Chlamydiaceae, which is the primary vaccine candidate antigen, recognize nonlinear epitopes conferred by the oligomeric conformation of the molecule. Protective MAbs failed to recognize oligomeric MOMP of the variant strain LLG, which bears amino acid substitutions in variable segments (V...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2001
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.69.8.4808-4815.2001